by John-Michael Dumais, Childrens Health Defense:
According to a panel of experts, led by Steve Kirsch, regulators are ignoring proof that Pfizer intentionally concealed the presence of contaminants in its COVID-19 vaccines. Those contaminants could threaten unborn babies whose mothers receive the vaccine, the experts said in a recent video.
More evidence that Pfizer deliberately concealed from regulators the presence of the simian virus 40 (SV40) gene promoter and other genetic sequences and contaminants in its COVID-19 vaccine surfaced last week in a new video.
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The video followed recent confirmation by Health Canada that Pfizer failed to disclose the SV40 sequence, violating transparency rules.
Steve Kirsch, founder of the Vaccine Safety Research Foundation, hosted the video panel. Panelists included Kevin McKernan, the genomics scientist who first identified the contamination in the vaccines, Dr. Byram Bridle, a vaccinologist from the University of Guelph in Canada and Chris Martenson, Ph.D., an economic researcher and founder and CEO of Peak Prosperity.
“If Health Canada wants to restore faith, they have to immediately recall this product,” Bridle said.
“Nobody’s calling for the stoppage of these vaccines because the experts say, ‘There’s nothing to see here,’” Kirsch said.
Contamination overview
McKernan’s testing — confirmed by “lots of other labs,” according to Bridle — revealed that COVID-19 mRNA vaccines from both Pfizer and Moderna contain bacterial plasmid DNA contamination.
McKernan said the plasmid DNA likely originates from the manufacturing process, where DNA plasmids from E. coli bacteria are used to generate the spike protein mRNA. Though it was supposed to be fully removed, DNA sequencing of vaccine vial contents shows remnants persist.
Both the plasmid DNA “backbone” and specific gene sequences have been detected, according to McKernan. The bacterial backbone itself could cause unintended immune reactions. For example, lipopolysaccharide (LPS), a component of the outer membrane of gram-negative bacteria like E. coli, is a known endotoxin, according to immunologist, biologist and biochemist Jessica Rose, Ph.D. LPS can, in sufficient quantities, cause septic shock.
Other contaminants include dsRNA or double-stranded RNA, McKernan said. This is formed during bacterial transcription of the plasmid during manufacturing. The human immune system identifies dsRNA as a sign of viral infection, which can trigger inflammatory cytokine production.
McKernan also found other foreign proteins, for example, those coding for antibiotic resistance or replication.
In a CHD.TV conversation last week with Children’s Health Defense (CHD) President Mary Holland and Brian Hooker, Ph.D., CHD’s senior director of science and research, McKernan said Pfizer tried to get rid of the extra DNA by “chewing it up with an enzyme [Deoxyribonuclease or DNase],” but that it didn’t work, McKernan speculated, because of the N1-methylpseudouridine (often referred to as “pseudouridine”) used in mRNA vaccines.
Pseudouridine is the artificial nucleotide base used to stabilize mRNA. Katalin Karikó, Ph.D., and Drew Weissman, M.D., Ph.D., made this discovery for which, along with their development of the lipid nanoparticle (LNP) encapsulation technology, the Nobel committee awarded them the Nobel Prize in Physiology or Medicine earlier this month.
However, plasmid DNA also contains functional gene sequences like promoters that can drive genetic expression, according to Bridle. The SV40 promoter is known to induce primary brain and bone cancers, malignant mesothelioma and lymphomas in laboratory animals. This sequence was never disclosed to regulators like Health Canada, Bridle said.
The SV40 promoter also facilitates the nuclear entry of foreign DNA, heightening the chance of integration into the human genome, McKernan said.
“SV40 is a well-published tool for gene therapy. If you want to get DNA into the nucleus, this is the shuttle that you use to get it done,” said McKernan in the World Council for Health panel earlier this month.
During the same panel, toxicologist Dr. Janci Chunn Lindsay, executive editor of the Journal of Toxicology Current Research, called SV40 a “super promoter,” saying that SV40 is “great at driving gene expression and if that should sit above an oncogene, of course you could have an explosion of an amplification in a cancer gene.”
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