from Your News:
Research highlights the neurotoxic effects of atrazine, linking it to brain cell aging and neurodegenerative diseases.
By yourNEWS Media Newsroom
A study published on December 13, 2024, has revealed that the widely used herbicide atrazine causes significant neurological damage, effectively accelerating the aging of brain cells. The findings raise serious concerns about the herbicide’s long-term impact on human health, particularly its link to neurodegenerative diseases.
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Research.0547 by yourNEWS Media
“Atrazine (AT), a widely utilized chemical herbicide, causes widespread contamination of agricultural water bodies. Recently, exposure to AT has been linked to the development of age-related neurodegenerative diseases (NDs), suggesting its neurotoxicity potential,” the study’s abstract stated.
The researchers identified the hypothalamus as a primary target of atrazine. This critical region of the brain, which plays a key role in the neuroendocrine system, exhibited significant structural damage following exposure.
“Our results indicated that AT exposure caused significant morphological and structural damage to the hypothalamus, leading to the loss of mature and intact neurons and microglial activation,” the study detailed.
The research further demonstrated that atrazine-induced damage is accompanied by cellular senescence, a condition associated with aging.
“AT induces senescence in these recruited HtNSCs by activating integrated stress response signaling. This consequently hinders the repair of damaged neurons by inhibiting HtNSC proliferation and differentiation,” the study stated. “Overall, our findings underscore the pivotal role of the integrated stress response pathway in AT-induced HtNSC senescence and hypothalamic damage.”
The study also provided preliminary evidence linking atrazine contamination to the development of neurodegenerative diseases, offering new insights into its neurotoxicity mechanisms.
Atrazine’s harmful effects are not limited to humans. Previous studies have documented its impact on other species, including amphibians. Research conducted at the University of California, Berkeley, demonstrated that atrazine exposure in male frogs led to chemical castration and feminization.
