by Dr. Joseph Mercola, Mercola:
STORY AT-A-GLANCE
- According to research published in December 2023, the mRNA COVID shots suffer high rates of ribosomal “frameshifting,” which causes your cells to produce off-target proteins that can trigger unintended immune reactions
- According to the authors, off-target cellular immune responses occur in 25% to 30% of people who have received the COVID shot
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- The U.S. Food and Drug Administration and Australia’s Therapeutic Goods Administration are refusing to release the RNA stability data they supposedly relied on when approving a change to Pfizer’s shot that allowed it to be transported and stored at temperatures of -20 degrees Celsius instead of -70 C
- The FDA also authorized Pfizer to swap the phosphate-buffered saline buffer used in the adult formulations, to a tromethamine (Tris) buffer in the children’s version. FDA did not require any kind of testing to be conducted, and no data have been released in support of its decision to allow the swap
- According to research published in 2023, the nanolipid in Comirnaty, made by Pfizer/BioNTech, is toxic to cells and triggers proinflammatory cytokines and reactive oxygen species that can disrupt the mitochondrial membrane causing it to release its content, cause RNA mistranslation, DNA mutations, destruction of the nuclear membrane and more. Frequent repetitions of COVID boosters and/or using mRNA in other vaccines poses a grave public health risk, the scientist warns
According to research published in the December 6, 2023, issue of Nature, the mRNA COVID shots suffer from high rates of ribosomal “frameshifting,” which causes your cells to produce off-target proteins with unknown effects.1,2,3 As explained in that paper:4
“A key feature of therapeutic IVT [in vitro-transcribed] mRNAs is that they contain modified ribonucleotides, which have been shown to decrease innate immunogenicity and can additionally increase mRNA stability, both of which are favorable characteristics for mRNA therapies …
Pseudouridine (Ψ) is known to increase misreading of mRNA stop codons in eukaryotes, and can affect misreading during prokaryotic mRNA translation. 1-methylΨ does not seem to affect codon misreading, but has been shown to affect protein synthesis rates and ribosome density on mRNAs, suggesting a direct effect on mRNA translation …
Here we demonstrate that incorporation of N1-methylpseudouridine into mRNA results in +1 ribosomal frameshifting in vitro and that cellular immunity in mice and humans to +1 frameshifted products from BNT162b2 vaccine mRNA translation occurs after vaccination.
The +1 ribosome frameshifting observed is probably a consequence of N1-methylpseudouridine-induced ribosome stalling during IVT mRNA translation, with frameshifting occurring at ribosome slippery sequences …
[T]hese data highlight potential off-target effects for future mRNA-based therapeutics and demonstrate the requirement for sequence optimization.”
Synthetic RNA Is Frequently Misread
In layman English, the inclusion of synthetic methylpseudouridine causes the ribosomes (which are responsible for reading the code) to misread the RNA’s instructions. RNA code consists of groups of three bases (codons) that must be read in the correct order for a desired protein to be created.
Because the methylpseudouridine is not a perfect fit, it causes the decoding process to stall and shift (hence the term “+1 ribosomal frameshifting”). There’s basically a stutter in the decoding process, as your cells don’t understand what’s being asked for, and this stuttering causes the decoding to skip a letter, thereby garbling the entire code.
As a result, unintended “nonsensical” proteins are produced instead of the desired SARS-CoV-2 spike. That, in turn, means that your immune system will not produce antibodies against SARS-CoV-2, but rather against these aberrant proteins.
According to the authors, off-target cellular immune responses occur in 25% to 30% of people who have received the COVID shot, and as noted by molecular virologist David Speicher Ph.D.:5
“Whenever our cells create an abundance of unintended proteins or prevent production of appropriate proteins it could lead to an unintended immune response with a huge potential to cause harm.”
Not knowing exactly what proteins are being produced is far from the only problem with these gene-based shots, though.
Why Are Regulators Hiding RNA Stability Data?
As reported by investigative journalist Maryanne Demasi, Ph.D., the U.S. Food and Drug Administration and Australia’s Therapeutic Goods Administration both refuse to release the RNA stability data they supposedly relied on when approving a change to Pfizer’s shot that allowed it to be transported and stored at temperatures of -20 degrees Celsius instead of -70 C.
Pfizer has also refused to disclose those data. Why is that? What do the data reveal that they don’t want us to see? Demasi writes:6
“… when the FDA granted authorization7 in December 2020, it specified the vaccine had to be stored between -80ºC and -60ºC, requiring special ultra-cold freezers, which proved challenging to areas with limited resources.
But by February 2021, Pfizer had apparently solved the problem. It submitted new ‘RNA stability data’ to the FDA demonstrating the vaccine could be stored in conventional freezers (-20ºC) and no longer required ultra-cold freezers.
The FDA approved8 the change swiftly. Two months later, Australia’s Therapeutic Goods Administration (TGA) also approved9 Pfizer’s application, allowing unopened vials to be stored at -20ºC for up to 2 weeks.
Storage temperature wasn’t the only change. Drug regulators also approved extensions to the vaccines’ expiry dates. Various batches of Pfizer’s vaccine, for example, had their expiry dates extended by one year (FDA10) or 6 months (TGA11).
But given the sensitivity of RNA to changes in temperature and storage duration, what stability data did the regulators rely on to green-light these decisions?”
As it stands, we have no idea, and that’s a problem. As Phillip Altman, who has more than four decades of experience in clinical trials and regulatory affairs, told Demasi,12 “It’s critically important to know about the stability of RNA in the vaccines because if the RNA disintegrates, then the efficacy of the vaccine goes down.”
Of course, over the past three years, evidence conclusively shows that the shots are near-useless when it comes to efficacy. What’s worse, efficacy actually becomes negative after a few months, meaning they leave you more prone to infection than your unjabbed peers.
Does RNA Instability Have Something to Do With ‘Hot Lots’?
Altman is also concerned about safety, because data reveal some shots contain far higher doses of mRNA than others, and such “hot lots” are associated with more adverse events and deaths.13 Mounting research shows the shots do not contain “nothing but intact RNA.”
They also contain fragments of RNA, as well as bits of DNA, both of which can have deleterious health effects. Demasi quotes David Wiseman, Ph.D., a research bioscientist involved in medical product development, who told her:14
“We need to know about the bits of RNA that are not intact. It’s possible that small fragments of mRNA also have biological effects such as inflammation or controlling how other RNA works.”
What Data Did FDA Rely on When Authorizing Buffer Swap?
The FDA also authorized another swap that affected RNA stability, and in this case, they appear to have done so without any testing whatsoever. In October 2021, Pfizer amended the formulation of its COVID jab for children aged 5 to 11 years, swapping out the phosphate-buffered saline used in the adult formulations, to a tromethamine (Tris) buffer.15
