from True Activist:
A study out of China is the first to test the effects of immune activation by vaccination (hep B/BCG) on brain development in rats.
A study out of China is the first to test the effects of immune activation by vaccination (hep B/BCG) on brain development in rats. Results indicate vaccines containing an aluminum adjuvant (i.e., hep B) spike cytokine levels in the hippocampus region of the brain, in particular, the cytokine interleukin-6 (IL-6), the key cytokine known for its dysregulating effect on neuronal circuitry and the key cytokine implicated in autism.
History of research into immune activation and autism
Before we get into the China study, it’s important to understand all of the previous research leading up to it.
In 2006, late Caltech scientist Dr. Paul Patterson and his colleagues were among the first to discover the implications of maternal immune activation and brain development in offspring.
In an article published in the Engineering & Science journal, titled “Pregnancy, Immunity, Schizophrenia, and Autism,” Patterson wrote that “brain-immune conversation actually starts during the development of the embryo, where the state of the mother’s immune system can alter the growth of cells in the fetal brain.”
Patterson and his team built on the work led by Carlos Pardo at Johns Hopkins, which discovered “neural inflammation” in postmortem examination of brains of patients with autism. Strangely, these autistic patients did not die due to any infections that would have caused the inflammation.
This research was the first to suggest “an ongoing, permanent immune-system activation in the brains of autistic people.”
In 2007 Patterson took this research further, publishing a study that found the culprit of this chronic brain inflammation — cytokine interleukin-6 (IL-6).
Cytokines are cell signaling molecules that aid cell to cell communication, stimulating the movement of cells toward sites of inflammation, infection, and trauma.
Patterson found that IL-6 was critical for mediating the behavioral and transcriptional changes in the neurology of the rat offspring.
This study was replicated by Patterson in 2012, which was more autism-specific, and reached the same conclusion: “These results indicate that [maternal immune activation] MIA yields male offspring with deficient social and communicative behavior, as well as high levels of repetitive behaviors, all of which are hallmarks of autism.”
In 2014, the M.I.N.D. Institute at UC-Davis replicated Dr. Patterson’s work in rhesus monkeys and found the same results.
Another 2012 study from Neuroscience agreed with Patterson — Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors.
The next question, then, was what causes immune activation that would lead to increased levels of IL-6 in the brain?
Aluminum bioaccumulates in the brain
Aluminum compounds (Al hydroxide and Al phosphate) are currently used in the hepatitis A, hepatitis B, diphtheria-tetanus-pertussis (DTaP, Tdap), Haemophilus influenza type b (Hib), human papillomavirus (HPV), and pneumococcus (PCV) vaccines.
Aluminum adjuvant “activates” the immune system, which induces long-term immunity to antigens in the vaccine.
Dr. Chris Shaw at the University of British Columbia did extensive research on injected aluminum in 2007 and 2009 and found “the results reported mirror previous work that has clearly demonstrated that aluminum, in both oral and injected forms, can be neurotoxic. Potential toxic mechanisms of action for aluminum may include enhancement of inflammation.”
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