from The Sleuth Journal:
Many diabetics already know about the benefits of a low-glycemic diet, but why haven’t they heard about turmeric, one of the world’s most extensively researched anti-diabetic plants?
A recent literature review published in the International Journal of Endocrinology and Metabolism titled, “Anti-Hyperglycemic Effect and Insulin Sensitizing Effects of Turmeric and Its Principle Constituent Curcumin,” adds promising new support to the notion that the ancient Indian spice turmeric may provide an ideal drug alternative to treating and perhaps even preventing type 2 diabetes, which has become of the world’s most prevalent diagnoses.
The study reviewed research published between 1998 to 2013 that indicates the active polyphenol in turmeric known as curcumin may provide an ideal intervention for type 2 diabetes, capable of mitigating characteristic pathophysiological hallmarks of the disease such as elevated blood sugar (hyperglycemia) and insulin resistance.
Nineteen of the studies reviewed were cell (in vitro) and animal (in vivo), all which showed beneficial effects. Five of the studies were human clinical trials using turmeric or curcumin, three of which were performed in those with either diabetes or prediabetes.
Amazingly, the animal and cell research literature review concluded that curcumin could improve the type 2 diabetic state through 10 distinctly different mechanisms, such as:
- Reduction in liver glucose production
- Reduction in liver glycogen production
- Stimulation of increased glucose uptake (by increasing GLUT4, GLUT2 and GLUT3 gene expressions)
- Increasing the activation of AMP kinase
- Promoting PPAR γ ligand- binding activity
- Suppressing hyperglycemia-induced inflammatory state
- Stimulating insulin secretion from pancreatic tissues
- Improvement in pancreatic cell function,
- Increasing phosphorylation of AKT
- Increasing insulin receptor β and reduction of insulin resistance
The human clinical research conducted on diabetic and pre-diabetic patients revealed that curcumin had the following beneficial effects:
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